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Target
Leukotriene A-4 hydrolase
Ligand
BDBM23978
Substrate
BDBM23991
Meas. Tech.
Enzyme Inhibition Assay
Ki
6000±n/a nM
Citation
 Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM23978
Synonyms:
(3Z)-3-[(3-phenylpropoxy)imino]-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | Tetralone-oxime derivative, 2e
Type:
Small organic molecule
Emp. Form.:
C19H22N2O
Mol. Mass.:
294.3908
SMILES:
NC1Cc2ccccc2C\C1=N\OCCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23991
Synonyms:
(2S)-2-amino-N-(4-nitrophenyl)propanamide | Ala-4-nitroanilide | Alanine para-nitroanilide | L-Alanine-4-nitroanilide
Type:
n/a
Emp. Form.:
C9H11N3O3
Mol. Mass.:
209.2019
SMILES:
C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: