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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM377896
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
101580±n/a nM
Citation
 Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent  US10266526 Publication Date 4/23/2019 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM377896
Synonyms:
N-((1r,4r)-4-aminocyclohexyl)-1-ethyl-3-methyl-1H-pyrazole-5-carboxamide | US10266526, Compound 27
Type:
Small organic molecule
Emp. Form.:
C13H22N4O
Mol. Mass.:
250.34
SMILES:
CCn1nc(C)cc1C(=O)N[C@H]1CC[C@H](N)CC1 |r,wU:11.11,wD:14.15,(-.62,1.93,;.71,2.69,;2.05,1.93,;3.51,2.4,;4.42,1.15,;5.96,1.15,;3.51,-.09,;2.05,.38,;.71,-.38,;.71,-1.93,;-.62,.38,;-1.95,-.38,;-1.95,-1.93,;-3.29,-2.69,;-4.62,-1.93,;-5.96,-2.69,;-4.62,-.38,;-3.29,.38,)|
Structure:
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