Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM262042
Substrate
n/a
Meas. Tech.
FGFR Enzymatic Assay 1
IC50
<10±n/a nM
Citation
 Lu, L; Shen, B; Sokolsky, A; Wang, X; Wu, L; Yao, W; Ye, Y Bicyclic heterocycles as FGFR4 inhibitors US Patent  US9708318 Publication Date 7/18/2017 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM262042
Synonyms:
2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dimethylamino)thiazol-4-yl)- 1'H-spiro[cyclopropane-1,4'- [2,7]naphthyridin]-3'(2'H)-one | US10251892, Example 160 | US10632126, Example 160 | US11173162, Example 160 | US9708318, 160
Type:
Small organic molecule
Emp. Form.:
C23H22F2N4O3S
Mol. Mass.:
472.508
SMILES:
COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2csc(n2)N(C)C)c1F
Structure:
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