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Target
Sodium/hydrogen exchanger 3
Ligand
BDBM381742
Substrate
n/a
Meas. Tech.
Cell-based activity under Prompt Conditions
IC50
2.51±n/a nM
Citation
 Carreras, C; Charmot, D; Jacobs, JW; Labonte, E; Lewis, JG NHE3-binding compounds and methods for inhibiting phosphate transport US Patent  US10272079 Publication Date 4/30/2019 
Target
Name:
Sodium/hydrogen exchanger 3
Synonyms:
NHE-3 | Na(+)/H(+) exchanger 3 | Nhe3 | SL9A3_RAT | Slc9a3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3
Type:
PROTEIN
Mol. Mass.:
93115.43
Organism:
Rattus norvegicus
Description:
ChEMBL_116967
Residue:
831
Sequence:
MWHPALGPGWKPLLALAVAVTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM
  
Inhibitor
Name:
BDBM381742
Synonyms:
US10272079, Compound 99
Type:
Small organic molecule
Emp. Form.:
C56H78N8O12S2
Mol. Mass.:
1119.395
SMILES:
O=C(NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3ccccc23)N2CCCC2)cc1)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3ccccc23)N2CCCC2)cc1 |r|
Structure:
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