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Target
Transthyretin
Ligand
BDBM50308343
Substrate
n/a
Meas. Tech.
The FP assay
IC50
301±n/a nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50308343
Synonyms:
(Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidine-2,4-dione | CHEMBL591504 | US10278929, Compound 8 | US11337935, Compound 8
Type:
Small organic molecule
Emp. Form.:
C11H7Br2NO3S
Mol. Mass.:
393.051
SMILES:
COc1c(Br)cc(\C=C2/SC(=O)NC2=O)cc1Br
Structure:
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