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Target
Transthyretin
Ligand
BDBM383208
Substrate
n/a
Meas. Tech.
Determination of Binding Constants of HITS to TTR
Kd
285±58.1 nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM383208
Synonyms:
US10278929, Compound 4 | US11337935, Compound 4
Type:
Small organic molecule
Emp. Form.:
C19H23Cl2N2O5
Mol. Mass.:
430.302
SMILES:
[NH3+]CCOCCOCCOc1c(Cl)cc(Nc2ccccc2C(O)=O)cc1Cl
Structure:
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