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Target
Transthyretin
Ligand
BDBM138371
Substrate
n/a
Meas. Tech.
Determination of Binding Constants of HITS to TTR
Kd
370±145.4 nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138371
Synonyms:
US10278929, Diclofenac | US8877795, Diclofenac
Type:
Small organic molecule
Emp. Form.:
C14H12ClNO3
Mol. Mass.:
277.703
SMILES:
OC(=O)Cc1ccccc1Nc1c(O)cccc1Cl
Structure:
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