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Target
Carbonic anhydrase 9
Ligand
BDBM13058
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
Ki
34±n/a nM
Citation
 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. Bioorg Med Chem Lett 18:4282-6 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 9
Synonyms:
CA-IX | Carbonic anhydrase IX (CAIX) | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Membrane antigen MN | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase 9 (CAIX) | RCC-associated antigen G250 | CAH9_HUMAN | CA9 | G250 | MN | Carbonic anhydrases; II & IX | Carbonic anhydrases IX
Type:
Enzyme
Mol. Mass.:
49669.03
Organism:
Human
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
459
Sequence:
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
  
Inhibitor
Name:
BDBM13058
Synonyms:
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate | CMT | CHEMBL286738 | STX64 | {9-oxo-8-oxatricyclo[8.5.0.0^{2,7}]pentadeca-1(10),2(7),3,5-tetraen-5-yl} sulfamate | 667COUMATE | BN83495 | 667-COUMATE
Type:
Small organic molecule
Emp. Form.:
C14H15NO5S
Mol. Mass.:
309.07
SMILES:
c1cc2c(cc1OS(=O)(=O)N)OC(=O)C3=C2CCCCC3
Structure:
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Substrate
Name:
BDBM10856
Synonyms:
methanedione | Carbon Dioxide
Type:
Small organic molecule
Emp. Form.:
CO2
Mol. Mass.:
43.99
SMILES:
C(=O)=O
Structure:
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