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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50242696
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
7.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50242696
Synonyms:
CHEMBL4083650 | US9932350, 2-5
Type:
Small organic molecule
Emp. Form.:
C17H21N5
Mol. Mass.:
295.3821
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:6.9,wD:3.2,(31.71,-18.38,;30.38,-17.61,;30.38,-16.07,;29.05,-18.38,;27.71,-17.61,;26.37,-18.39,;26.38,-19.92,;27.72,-20.69,;29.05,-19.92,;25.06,-20.69,;25.06,-22.23,;26.4,-22.99,;26.41,-24.54,;25.07,-25.32,;23.74,-24.55,;22.41,-25.33,;21.07,-24.56,;21.07,-23.01,;22.4,-22.24,;23.74,-23.01,;19.74,-22.24,;18.41,-21.48,)|
Structure:
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