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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50242695
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
9.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50242695
Synonyms:
CHEMBL4068395 | US9932350, 2-6
Type:
Small organic molecule
Emp. Form.:
C16H21BrN4
Mol. Mass.:
349.269
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(Br)cc12 |r,wU:6.9,wD:3.2,(16.64,-34.34,;15.3,-33.58,;15.3,-32.04,;13.97,-34.35,;12.63,-33.58,;11.3,-34.36,;11.31,-35.89,;12.64,-36.66,;13.97,-35.89,;9.98,-36.66,;9.99,-38.2,;11.32,-38.96,;11.33,-40.51,;10,-41.29,;8.66,-40.52,;7.33,-41.3,;6,-40.53,;6,-38.98,;4.67,-38.21,;7.33,-38.21,;8.66,-38.98,)|
Structure:
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