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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384563
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
12.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384563
Synonyms:
US9932350, 2-15 | [(4-{[trans-4- (dimethylamino)cyclohexyl] aminoiquinazolin-6- yl)oxy]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C18H23N5O
Mol. Mass.:
325.4081
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCC#N)cc12 |r,wU:3.2,wD:6.9,(2.31,-6,;3.08,-4.67,;4.62,-4.67,;2.31,-3.33,;.77,-3.33,;,-2,;.77,-.67,;2.31,-.67,;3.08,-2,;,.67,;-1.54,.67,;-2.31,-.67,;-3.85,-.67,;-4.62,.67,;-3.85,2,;-4.62,3.33,;-3.85,4.67,;-2.31,4.67,;-1.54,6,;,6,;.77,4.67,;1.54,3.33,;-1.54,3.33,;-2.31,2,)|
Structure:
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