Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384582
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
4.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384582
Synonyms:
4-({trans-4-[(2S or 2R)- 2-methylmorpholin-4- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-16 | US9932350, 3-17
Type:
Small organic molecule
Emp. Form.:
C20H25N5O
Mol. Mass.:
351.4454
SMILES:
CC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:10.14,wD:7.7,(5.78,3.33,;4.24,3.33,;3.46,2,;1.92,2,;1.15,3.33,;1.92,4.67,;3.47,4.67,;1.15,.67,;-.39,.67,;-1.16,-.67,;-.39,-2,;1.15,-2,;1.92,-.67,;-1.16,-3.33,;-2.7,-3.33,;-3.47,-4.67,;-5.01,-4.67,;-5.78,-3.33,;-5.01,-2,;-5.78,-.67,;-5.01,.67,;-3.47,.67,;-2.7,-.67,;-3.47,-2,;-2.7,2,;-1.93,3.33,)|
Structure:
Search PDB for entries with ligand similarity: