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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50242700
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
8.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50242700
Synonyms:
CHEMBL4088745 | US9932350, 3-20
Type:
Small organic molecule
Emp. Form.:
C20H26N6O2S
Mol. Mass.:
414.524
SMILES:
CS(=O)(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:13.17,wD:10.10,(38.83,-2.39,;37.49,-1.61,;36.72,-.27,;38.26,-.27,;36.16,-2.38,;36.15,-3.92,;34.83,-4.69,;33.5,-3.92,;33.49,-2.38,;34.83,-1.61,;32.17,-4.69,;30.83,-3.92,;29.49,-4.69,;29.51,-6.23,;30.84,-7,;32.17,-6.23,;28.18,-7,;28.19,-8.54,;29.52,-9.3,;29.53,-10.85,;28.2,-11.62,;26.86,-10.86,;25.53,-11.63,;24.19,-10.86,;24.2,-9.32,;25.53,-8.55,;26.86,-9.31,;22.86,-8.55,;21.52,-7.78,)|
Structure:
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