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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384593
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
8.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384593
Synonyms:
4-({trans-4-[2- (fluoromethyl)morpholin- 4- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-27
Type:
Small organic molecule
Emp. Form.:
C20H24FN5O
Mol. Mass.:
369.4359
SMILES:
FCC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:11.15,wD:8.8,(.38,-8,;1.93,-8,;2.69,-6.67,;1.93,-5.33,;2.69,-4,;4.23,-4,;5,-5.33,;4.23,-6.67,;1.93,-2.67,;2.69,-1.33,;1.93,,;.38,,;-.38,-1.33,;.38,-2.67,;-.38,1.33,;-1.93,1.33,;-2.69,,;-4.23,,;-5,1.33,;-4.23,2.67,;-5,4,;-4.23,5.33,;-2.69,5.33,;-1.93,4,;-2.69,2.67,;-1.93,6.67,;-1.15,8,)|
Structure:
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