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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384598
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
15.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384598
Synonyms:
4-({trans-4- [cyclopropyl(methyl) amino]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-32
Type:
Small organic molecule
Emp. Form.:
C19H23N5
Mol. Mass.:
321.4194
SMILES:
CN(C1CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:5.5,wD:8.12,(1.64,-6.67,;2.41,-5.33,;3.95,-5.33,;5.29,-4.56,;5.29,-6.1,;1.64,-4,;.1,-4,;-.67,-2.67,;.1,-1.33,;1.64,-1.33,;2.41,-2.67,;-.67,,;-2.21,,;-2.98,-1.33,;-4.52,-1.33,;-5.29,,;-4.52,1.33,;-5.29,2.67,;-4.52,4,;-2.98,4,;-2.21,2.67,;-2.98,1.33,;-2.21,5.33,;-1.44,6.67,)|
Structure:
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