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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384604
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
15.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384604
Synonyms:
4-({trans-4-[(3R)-3- hydroxypyrrolidin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-38
Type:
Small organic molecule
Emp. Form.:
C19H23N5O
Mol. Mass.:
337.4188
SMILES:
O[C@@H]1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:6.6,wD:9.13,1.0,(5.52,-7.05,;4.19,-6.28,;2.95,-7.19,;1.7,-6.28,;2.18,-4.82,;3.72,-4.82,;1.41,-3.48,;-.13,-3.48,;-.9,-2.15,;-.13,-.82,;1.41,-.82,;2.18,-2.15,;-.9,.52,;-2.44,.52,;-3.21,-.82,;-4.75,-.82,;-5.52,.52,;-4.75,1.85,;-5.52,3.19,;-4.75,4.52,;-3.21,4.52,;-2.44,3.19,;-3.21,1.85,;-2.44,5.85,;-1.67,7.19,)|
Structure:
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