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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384630
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384630
Synonyms:
4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]amino} quinazoline-6-carbonitrile | US9932350, 6-2
Type:
Small organic molecule
Emp. Form.:
C21H26N6O
Mol. Mass.:
378.4707
SMILES:
CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:12.16,wD:9.9,(3.47,-8.67,;4.23,-7.34,;5.78,-7.34,;3.47,-6,;1.93,-6,;1.15,-4.67,;1.93,-3.33,;3.47,-3.33,;4.23,-4.67,;1.15,-2,;1.93,-.67,;1.15,.67,;-.38,.67,;-1.15,-.67,;-.38,-2,;-1.15,2,;-2.69,2,;-3.47,.67,;-5,.67,;-5.78,2,;-5,3.33,;-5.78,4.67,;-5,6,;-3.47,6,;-2.69,4.67,;-3.47,3.33,;-2.69,7.34,;-1.93,8.67,)|
Structure:
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