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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384631
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
8.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384631
Synonyms:
4-({trans-4-[4-(2,2- dimethylpropanoyl) piperazin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-3
Type:
Small organic molecule
Emp. Form.:
C24H32N6O
Mol. Mass.:
420.5505
SMILES:
CC(C)(C)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:15.19,wD:12.12,(5.78,-6,;5,-7.34,;5.78,-8.67,;6.54,-7.34,;3.47,-7.34,;2.69,-8.67,;2.69,-6,;1.15,-6,;.38,-4.67,;1.15,-3.33,;2.69,-3.33,;3.47,-4.67,;.38,-2,;1.15,-.67,;.38,.67,;-1.15,.67,;-1.93,-.67,;-1.15,-2,;-1.93,2,;-3.47,2,;-4.23,.67,;-5.78,.67,;-6.54,2,;-5.78,3.33,;-6.54,4.67,;-5.78,6,;-4.23,6,;-3.47,4.67,;-4.23,3.33,;-3.47,7.34,;-2.69,8.67,)|
Structure:
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