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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384635
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
14.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384635
Synonyms:
4-({trans-4-[4-(2- fluoropropanoyl)piperazin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-7
Type:
Small organic molecule
Emp. Form.:
C22H27FN6O
Mol. Mass.:
410.4878
SMILES:
CC(F)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:14.18,wD:11.11,(6.16,-6,;5.39,-7.34,;6.16,-8.67,;3.85,-7.34,;3.08,-8.67,;3.08,-6,;1.54,-6,;.77,-4.67,;1.54,-3.33,;3.08,-3.33,;3.85,-4.67,;.77,-2,;1.54,-.67,;.77,.67,;-.77,.67,;-1.54,-.67,;-.77,-2,;-1.54,2,;-3.08,2,;-3.85,.67,;-5.39,.67,;-6.16,2,;-5.39,3.33,;-6.16,4.67,;-5.39,6,;-3.85,6,;-3.08,4.67,;-3.85,3.33,;-3.08,7.34,;-2.31,8.67,)|
Structure:
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