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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384636
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
15.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384636
Synonyms:
4-[(trans-4-{4-[(1- methylcyclopropyl) carbonyl]piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile | US9932350, 6-8
Type:
Small organic molecule
Emp. Form.:
C24H30N6O
Mol. Mass.:
418.5346
SMILES:
CC1(CC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:15.20,wD:12.13,(5.88,-8.67,;5.11,-7.34,;5.11,-5.8,;6.44,-6.57,;3.57,-7.34,;2.8,-8.67,;2.8,-6,;1.26,-6,;.49,-4.67,;1.26,-3.33,;2.8,-3.33,;3.57,-4.67,;.49,-2,;1.26,-.67,;.49,.67,;-1.05,.67,;-1.82,-.67,;-1.05,-2,;-1.82,2,;-3.36,2,;-4.13,.67,;-5.67,.67,;-6.44,2,;-5.67,3.33,;-6.44,4.67,;-5.67,6,;-4.13,6,;-3.36,4.67,;-4.13,3.33,;-3.36,7.34,;-2.59,8.67,)|
Structure:
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