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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384643
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
10.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384643
Synonyms:
4-({trans-4-[4- (cyclobutylcarbonyl) piperazin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-15
Type:
Small organic molecule
Emp. Form.:
C24H30N6O
Mol. Mass.:
418.5346
SMILES:
O=C(C1CCC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:15.20,wD:12.13,(2.38,-8.67,;3.15,-7.34,;4.69,-7.34,;5.77,-8.42,;6.86,-7.34,;5.77,-6.25,;2.38,-6,;3.15,-4.67,;2.38,-3.33,;.84,-3.33,;.07,-4.67,;.84,-6,;.07,-2,;.84,-.67,;.07,.67,;-1.47,.67,;-2.24,-.67,;-1.47,-2,;-2.24,2,;-3.78,2,;-4.55,.67,;-6.09,.67,;-6.86,2,;-6.09,3.33,;-6.86,4.67,;-6.09,6,;-4.55,6,;-3.78,4.67,;-4.55,3.33,;-3.78,7.34,;-3.01,8.67,)|
Structure:
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