Reaction Details
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Report a problem with these dataTarget
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384645
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
9.00±n/a nM
Citation
Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent US9932350 Publication Date 4/3/2018 More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM384645
Synonyms:
4-({trans-4-[4- (cyclopropylacetyl) piperazin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-17
Type:
Small organic molecule
Emp. Form.:
C24H30N6O
Mol. Mass.:
418.5346
SMILES:
O=C(CC1CC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:15.20,wD:12.13,(2.41,-7.9,;3.18,-6.57,;4.72,-6.57,;5.49,-7.9,;5.49,-9.44,;6.83,-8.67,;2.41,-5.23,;3.18,-3.9,;2.41,-2.56,;.87,-2.56,;.1,-3.9,;.87,-5.23,;.1,-1.23,;.87,.1,;.1,1.44,;-1.44,1.44,;-2.21,.1,;-1.44,-1.23,;-2.21,2.77,;-3.75,2.77,;-4.52,1.44,;-6.06,1.44,;-6.83,2.77,;-6.06,4.1,;-6.83,5.44,;-6.06,6.77,;-4.52,6.77,;-3.75,5.44,;-4.52,4.1,;-3.75,8.11,;-2.98,9.44,)|
Structure:
