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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384646
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
10.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384646
Synonyms:
4-({trans-4-[4-(oxetan-3- ylacetyl)piperazin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-18
Type:
Small organic molecule
Emp. Form.:
C24H30N6O2
Mol. Mass.:
434.534
SMILES:
O=C(CC1COC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:16.21,wD:13.14,(2.34,-7.73,;3.11,-6.39,;4.65,-6.39,;5.42,-7.73,;6.9,-8.12,;6.51,-9.61,;5.02,-9.21,;2.34,-5.06,;3.11,-3.72,;2.34,-2.39,;.8,-2.39,;.03,-3.72,;.8,-5.06,;.03,-1.06,;.8,.28,;.03,1.61,;-1.51,1.61,;-2.28,.28,;-1.51,-1.06,;-2.28,2.94,;-3.82,2.94,;-4.59,1.61,;-6.13,1.61,;-6.9,2.94,;-6.13,4.28,;-6.9,5.61,;-6.13,6.94,;-4.59,6.94,;-3.82,5.61,;-4.59,4.28,;-3.82,8.28,;-3.05,9.61,)|
Structure:
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