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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384650
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
9.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384650
Synonyms:
4-({trans-4-[4-(3- hydroxypropanoyl) piperazin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 6-22
Type:
Small organic molecule
Emp. Form.:
C22H28N6O2
Mol. Mass.:
408.4967
SMILES:
OCCC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:14.18,wD:11.11,(6.93,-8.67,;5.39,-8.67,;4.62,-7.34,;3.08,-7.34,;2.31,-8.67,;2.31,-6,;3.08,-4.67,;2.31,-3.33,;.77,-3.33,;,-4.67,;.77,-6,;,-2,;.77,-.67,;,.67,;-1.54,.67,;-2.31,-.67,;-1.54,-2,;-2.31,2,;-3.85,2,;-4.62,.67,;-6.16,.67,;-6.93,2,;-6.16,3.33,;-6.93,4.67,;-6.16,6,;-4.62,6,;-3.85,4.67,;-4.62,3.33,;-3.85,7.34,;-3.08,8.67,)|
Structure:
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