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Target
Proto-oncogene Wnt-1
Ligand
BDBM384725
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
>10000±n/a nM
Citation
 KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof US Patent  US10285983 Publication Date 5/14/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM384725
Synonyms:
US10285983, Compound 28
Type:
Small organic molecule
Emp. Form.:
C24H15FN6
Mol. Mass.:
406.4145
SMILES:
Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1ccccn1
Structure:
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