Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM246853
Substrate
n/a
Meas. Tech.
TAM Enzymatic Assay
Temperature
298.15±n/a K
IC50
300±n/a nM
Comments
extracted
Citation
 Li, Y; Burns, DM Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors US Patent  US9708333 Publication Date 7/18/2017 
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM246853
Synonyms:
4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,1'H-4,4'- bipyrazol-1- yl)azetidin-1-yl]-2,5- difluoro-N-[(1S)- 2,2,2-trifluoro-1- methylethyl] benzamide | US10053465, 2 | US10065963, Compound 2 | US10125150, Example 2 | US10336759, # 2 | US10435392, Example 17 | US10479803, Example 2D | US10519163, Example 2 | US10675284, Example 2 | US11084822, Example 2 | US11130767, # 2 | US11136326, Example 2 | US11304949, Compound 4 | US11324749, Comp. No. 4 | US11591318, Example 7 | US11596632, Comp. No. 4 | US20240058343, Compound 4 | US9732097, Example 2 | US9926301, Example 17
Type:
Small organic molecule
Emp. Form.:
C23H22F5N7O
Mol. Mass.:
507.4591
SMILES:
C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: