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Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM26189
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
Ki
8700±n/a nM
Citation
 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem 16:7424-8 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA)
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM26189
Synonyms:
α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XII | 1,3-dihydroxybenzene | CHEMBL24147 | US9688816, 4 | benzene-1,3-diol | phenol derivative, 3
Type:
Small organic molecule
Emp. Form.:
C6H6O2
Mol. Mass.:
110.1106
SMILES:
Oc1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10856
Synonyms:
Carbon Dioxide | methanedione
Type:
Small organic molecule
Emp. Form.:
CO2
Mol. Mass.:
44.0095
SMILES:
O=C=O
Structure:
Search PDB for entries with ligand similarity: