Reaction Details Report a problem with these data
Target
Proline-rich AKT1 substrate 1
Ligand
BDBM386027
Substrate
n/a
Meas. Tech.
AKT Enzyme Assay
IC50
750±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent  US10287300 Publication Date 5/14/2019 
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
  
Inhibitor
Name:
BDBM386027
Synonyms:
4-{4-[1-(4-chloro-phenyl)-2-(piperidin-yl)-ethyl]-piperazin-1-yl}-7,8-dihydro-5H-pteridin-6-one | US10287300, Compound A32
Type:
Small organic molecule
Emp. Form.:
C23H30ClN7O
Mol. Mass.:
455.984
SMILES:
Clc1ccc(cc1)C(CN1CCCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12
Structure:
Search PDB for entries with ligand similarity: