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Target
Store-operated calcium entry-associated regulatory factor
Ligand
BDBM387314
Substrate
n/a
Meas. Tech.
SOCE inhibition
IC50
<1000±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Store-operated calcium entry-associated regulatory factor
Synonyms:
HBV X-transactivated gene 3 protein | HBV XAg-transactivated protein 3 | Protein FOAP-7 | SARAF | SOCE-associated regulatory factor | TMEM66 | Transmembrane protein 66 | XTP3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36978.81
Organism:
Homo sapiens (Human)
Description:
Q96BY9
Residue:
339
Sequence:
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
  
Inhibitor
Name:
BDBM387314
Synonyms:
2- Chloro-6-fluoro-N- (2′-methoxy-5′-(4- methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2-yl)[1,1′- biphenyl]-4- yl)benzamide | US10292981, Example 41
Type:
Small organic molecule
Emp. Form.:
C23H17ClFN3O4
Mol. Mass.:
453.85
SMILES:
COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2Cl)cc1)-c1nn(C)c(=O)o1
Structure:
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