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Target
TGF-beta receptor type-2
Ligand
BDBM387351
Substrate
n/a
IC50
39.0±n/a nM
Citation
 Borzilleri, RM; Fink, BE; Harikrishnan, LS; Sankara Warrier, J TGF beta receptor antagonists US Patent  US10292985 Publication Date 5/21/2019 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM387351
Synonyms:
5-fluoro-2-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}pyrrolo[2,1-f][1,2,4]triazin-2-yl)pyridine | US10292985, Example 33
Type:
Small organic molecule
Emp. Form.:
C18H11FN6
Mol. Mass.:
330.3185
SMILES:
Fc1ccc(nc1)-c1nc(-n2ccc3cnccc23)c2cccn2n1
Structure:
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