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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26668
Substrate
S6 Peptide Substrate
Meas. Tech.
Kinase Inhibition Assay
pH
7.6±n/a
Temperature
303.15±n/a K
Ki
11±n/a nM
Citation
 Pierce, AC; Jacobs, M; Stuver-Moody, C Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem 51:1972-5 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26668
Synonyms:
CHEMBL494360 | N-cyclohexyl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-a]pyridin-6-amine | triazolopyridazine compound, 1
Type:
Small organic molecule
Emp. Form.:
C18H18F3N5
Mol. Mass.:
361.3642
SMILES:
FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCCCC3)nn12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
S6 Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1118.34
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
RRRLSSLRA