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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM26742
Substrate
BDBM22988
Meas. Tech.
FAAH Inhibition Assay
pH
9±n/a
Temperature
295.15±n/a K
IC50
670±n/a nM
Citation
 Sit, SY; Conway, C; Bertekap, R; Xie, K; Bourin, C; Burris, K; Deng, H Novel inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett 17:3287-91 (2007) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM26742
Synonyms:
bisarylimidazole derivative, 1 | methyl 2-[4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
Type:
Small organic molecule
Emp. Form.:
C24H20N2O3
Mol. Mass.:
384.4272
SMILES:
COC(=O)COc1ccc(cc1)-n1cnc(c1-c1ccccc1)-c1ccccc1
Structure:
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Substrate
Name:
BDBM22988
Synonyms:
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide | AEA | ANANDAMIDE | Arachidonoyl ethanolamide | Arachidonoyl ethanolamide (AEA) | Arachidonoylethanolamide (AEA) | Arachidonylethanolamide | CHEMBL15848 | [14C]Anandamide | [3H]Anandamide
Type:
radiolabeled substrate
Emp. Form.:
C22H37NO2
Mol. Mass.:
347.5347
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO
Structure:
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