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Target
Tyrosine-protein kinase Fgr
Ligand
BDBM387845
Substrate
n/a
Meas. Tech.
Kinase Screening Assay
IC50
55.0±n/a nM
Citation
 Unciti-Broceta, A; Fraser, C; O. Carragher, N Compounds US Patent  US10294227 Publication Date 5/21/2019 
Target
Name:
Tyrosine-protein kinase Fgr
Synonyms:
FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr
Type:
protein
Mol. Mass.:
59469.88
Organism:
Homo sapiens (Human)
Description:
P09769
Residue:
529
Sequence:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
  
Inhibitor
Name:
BDBM387845
Synonyms:
US10294227, Code 402
Type:
Small organic molecule
Emp. Form.:
C21H27N9
Mol. Mass.:
405.4994
SMILES:
CN(C)C1CCN(CCn2nc(-c3cnc4[nH]ccc4c3)c3c(N)ncnc23)CC1
Structure:
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