Reaction Details Report a problem with these data
Target
Carbonic anhydrase 5B, mitochondrial
Ligand
BDBM26998
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
pH
7.5000±n/a
Temperature
293.1500±n/a K
Ki
134±n/a nM
Citation
 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem 17:1214-21 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5B, mitochondrial
Synonyms:
Carbonic anhydrase VB (CA VB) | CA-VB | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase 5B (CA VB) | Carbonate dehydratase VB | Carbonic anhydrase 5B, mitochondrial | CAH5B_HUMAN | CA5B | Carbonic anhydrase V | Carbonic Anhydrase VB
Type:
Enzyme
Mol. Mass.:
36440.83
Organism:
Human
Description:
Human (cloned) isozyme
Residue:
317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
  
Inhibitor
Name:
BDBM26998
Synonyms:
trichloromethiazide, 6 | 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide | TRICHLORMETHIAZIDE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10856
Synonyms:
methanedione | Carbon Dioxide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: