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Target
Calcium-dependent protein kinase 1
Ligand
BDBM50200562
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5.00±n/a nM
Citation
 Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent  US9956214 Publication Date 5/1/2018 
Target
Name:
Calcium-dependent protein kinase 1
Synonyms:
Calcium-dependent protein kinase 1 (CDPK1)
Type:
Protein
Mol. Mass.:
76617.33
Organism:
Cryptosporidium parvum
Description:
Q6S4W0
Residue:
677
Sequence:
MLNIEQNADECAKRVGANMVPVLHNVTEECNIKAEEKEIVPEVEEAKSESNNCLDSDDYLEGHIYAAMCTKCAGELQQKLNPTEPYRDPKKVSGKEQISRGLIIESKSFVDANKNIKFSKRSDKNEYAGLCSSPEVTTPNGERETSTDSNIKNTESTKVSHGIFDRTCLIQEHALVNRNINDFYELNLGNLGRGSYGSVVKAIDKQSGAQRAVKIILKPKLENINRLKREILIMKRLDHPNIIKLFEVFEDTNYLYFVMEICTGGELFDRIIKRGHFSERYAAVIMRQVFSAIAYCHSNEFMHRDLKPENLLFSDSSPNSLLKVIDWGFAAKCPKTHKFTSVVGTPYYVAPEVLYGSYSKLCDLWSAGVILYILLCGYPPFHGKDNVEILRKVKIGQYSLEHNSWKYVSDSAKDLIKRLLMTDPNKRISAQDALNHPWIKSQISSPNTADATYFTNDVCNSLLARFRDFQRQSKLKKLALTCVAYHLNDADIGALQKLFSTLDRNGDGVLTINEIRSALHKIQNVSQLGDDIDNLLMELDTDGNGRIDYTEFIAASIDHKLYEQESLCKAAFKVFDLDMDGRISPQELSRVLNITFLQEAFEQSTIDSLLKEVDINQDGYIDFNEFMKMMMGDKHEQKLETKVQKIEDEGSGNKKLSKGGIISDIFGATSIFKKLNN
  
Inhibitor
Name:
BDBM50200562
Synonyms:
CHEMBL3985876 | US9518026, Example 81 | US9956214, Compound 1645
Type:
Small organic molecule
Emp. Form.:
C22H27N5O3
Mol. Mass.:
409.4815
SMILES:
CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1
Structure:
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