Reaction Details Report a problem with these data
Target
Adenosine deaminase
Ligand
BDBM28378
Substrate
BDBM14487
Meas. Tech.
ADA Enzyme Inhibition Assay
pH
7.2000±n/a
Temperature
303.1500±n/a K
Comments
Nonactive.
Citation
 La Motta, C; Sartini, S; Mugnaini, L; Salerno, S; Simorini, F; Taliani, S; Marini, AM; Da Settimo, F; Lavecchia, A; Novellino, E; Antonioli, L; Fornai, M; Blandizzi, C; Del Tacca, M Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. J Med Chem 52:1681-92 (2009) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
Adenosine aminohydrolase | ADA_BOVIN | ADA
Type:
Enzyme
Mol. Mass.:
40910.44
Organism:
Bovine
Description:
n/a
Residue:
363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
  
Inhibitor
Name:
BDBM28378
Synonyms:
2-decyl-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one | pyrazolo[3,4-d]pyrimidin-4-one, 9b
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM14487
Synonyms:
[U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | N6-Methylado | cid_191 | Adenine-beta-D-arabinofuranoside | Adenosine
Type:
Nucleoside or nucleotide
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: