Reaction Details Report a problem with these data
Target
D-alanine--D-alanyl carrier protein ligase
Ligand
BDBM392801
Substrate
n/a
Meas. Tech.
in vitro DltA activity assay
IC50
4.70±n/a nM
Citation
Atamanyuk, D; Chevreuil, F; Faivre, F; Lecointe, N; Ledoussal, B; Oliveira, C; Simon, C; Gerusz, V Heteroaromatic derivatives and their use as pharmaceuticals US Patent US10301305 Publication Date 5/28/2019
More Info.:
Target
Name:
D-alanine--D-alanyl carrier protein ligase
Synonyms:
D-alanine--poly(phosphoribitol) ligase subunit 1 | DAE | DCL | dltA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56357.51
Organism:
Enterococcus faecalis (strain ATCC 700802 / V583)
Description:
n/a
Residue:
506
Sequence:
MEKVINMIQTIDEWARKEPQRPVYLTEEKVSTYGELKEKSDNLAAYLAELKTDKSAIVVYGELDFEMIVSFLGASKAGFSYIPIDAHTPKERIELILNVAKPTAVIAVHEWPELATEVPVITAEELTEMMMHAPRHAPALMPVTGASNYYIIFTSGTTGVPKGVQISHDNLVSFTNWLLQDFGLEEGARFLAQAPYSFDLSVMSIYPALALGGSLTPLPNEIINDFKQLFTRLPQLTIDVWVSTPSFIELCLMEPSFDGEHLPALRTFLFCGEELPKPTAEKLAARFPTAHIYNTYGPTEATVAISAIEITQEVLKSVQRLPIGYVKEDTQIYIMEGMSKLPAGEIGEIVIAGPSVSKGYLNNPAKTAEAFFQLDGVPAYRTGDAGKLVDNLLQYEGRLDFQIKLHGYRIELEEVDHHLTNVSYVKQAVVVPKYQGNKVQQLIAYVVPQAHEFSSDFQLTKAIKQELATLTMDYMIPQKFVYVEQLPLTSNGKIDRKGLMNEVNAT
Inhibitor
Name:
BDBM392801
Synonyms:
7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[(1-methylpyrrolidin-2-yl)methoxy]-3H-benzimidazole-4-carboxamide methanesulfonic acid salt | US10301305, Example 233
Type:
Small organic molecule
Emp. Form.:
C22H25N5O3
Mol. Mass.:
407.4656
SMILES:
CN1CCCC1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O