Reaction Details Report a problem with these data
Target
Cholesterol 24-hydroxylase
Ligand
BDBM393282
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
7.10±n/a nM
Citation
 Koike, T; Ikeda, S Radiolabeled compounds US Patent  US9963443 Publication Date 5/8/2018 
Target
Name:
Cholesterol 24-hydroxylase
Synonyms:
CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H)
Type:
Protein
Mol. Mass.:
56834.45
Organism:
Homo sapiens (Human)
Description:
Q9Y6A2
Residue:
500
Sequence:
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
  
Inhibitor
Name:
BDBM393282
Synonyms:
US9963443, Reference Example 4
Type:
Small organic molecule
Emp. Form.:
C18H22FN5O
Mol. Mass.:
343.3986
SMILES:
Cc1cnn(c1)-c1ccncc1N1CCC(CC1)C(=O)N1CC(F)C1
Structure:
Search PDB for entries with ligand similarity: