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Target
Cholesterol 24-hydroxylase
Ligand
BDBM393288
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
17.0±n/a nM
Citation
 Koike, T; Ikeda, S Radiolabeled compounds US Patent  US9963443 Publication Date 5/8/2018 
Target
Name:
Cholesterol 24-hydroxylase
Synonyms:
CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H)
Type:
Protein
Mol. Mass.:
56834.45
Organism:
Homo sapiens (Human)
Description:
Q9Y6A2
Residue:
500
Sequence:
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
  
Inhibitor
Name:
BDBM393288
Synonyms:
US9963443, Reference Example 14
Type:
Small organic molecule
Emp. Form.:
C19H24ClN5O2
Mol. Mass.:
389.879
SMILES:
CN([C@@H]1CCOC1)C(=O)C1CCN(CC1)c1cnccc1-n1cc(Cl)cn1
Structure:
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