Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM393434
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
0.005±n/a nM
Citation
 Burch, J; Chen, H; Wang, X Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9963446 Publication Date 5/8/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM393434
Synonyms:
N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxepan-2-yl)-1- methyl-1H-pyrazol-4-yl)-2-(2,6- difluorophenyl)thiazole-4- carboxamide | US9963446, Example 121
Type:
Small organic molecule
Emp. Form.:
C21H22F3N5O2S
Mol. Mass.:
465.492
SMILES:
C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r|
Structure:
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