Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM393471
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
56.5±n/a nM
Citation
 Merce-Vidal, R; Díaz-Fernández, J; Almansa-Rosales, C Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators US Patent  US9963453 Publication Date 5/8/2018 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM393471
Synonyms:
(S)-2-(4- methyl- piperazin-1- yl)-1- 3,4,10,10a- tetrahydro-pyrazino[1,2-a]indol-2(1H)-yl)propan-1-one | US9963453, 34
Type:
Small organic molecule
Emp. Form.:
C19H28N4O
Mol. Mass.:
328.4518
SMILES:
C[C@H](N1CCN(C)CC1)C(=O)N1CCN2[C@@H](Cc3ccccc23)C1 |r|
Structure:
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