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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM394123
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
7110±370 nM
Citation
 Cavalli, A; Prati, F; Bottegoni, G; Favia, AD; Pizzirani, D; Scarpelli, R; Bolognesi, ML Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer''s disease US Patent  US9975861 Publication Date 5/22/2018 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM394123
Synonyms:
US9975861, 3 | US9975861, 4 | US9975861, 5
Type:
Small organic molecule
Emp. Form.:
C11H13FN4O
Mol. Mass.:
236.2455
SMILES:
CCNC1=NC(NC(=O)N1)c1ccc(F)cc1 |t:3|
Structure:
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