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Target
Tissue alpha-L-fucosidase
Ligand
BDBM394398
Substrate
n/a
Meas. Tech.
In Vitro Fucosidase Inhibition
IC50
1500±n/a nM
Citation
 Zankel, TC; Isbell, SL; Ko, AA Fucosidase inhibitors US Patent  US10308607 Publication Date 6/4/2019 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM394398
Synonyms:
US10308607, Compound IV
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5
Mol. Mass.:
380.3939
SMILES:
C[C@@H]1N\C(=C/C(=O)Nc2cccc3-c4ccccc4C(=O)c23)[C@@H](O)[C@H](O)[C@@H]1O |r|
Structure:
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