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Target
Cyclin-dependent kinase 7
Ligand
BDBM395705
Substrate
n/a
Meas. Tech.
CDK7 Kinase Activity
IC50
>1000±n/a nM
Citation
 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Inhibitors of cyclin-dependent kinase 7 (CDK7) US Patent  US10308648 Publication Date 6/4/2019 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM395705
Synonyms:
4-amino-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)tricyclo[3.3.1.13,7]decanyl)benzamide | US10308648, Compound 100
Type:
Small organic molecule
Emp. Form.:
C26H30N2O4
Mol. Mass.:
434.5274
SMILES:
O=C(NC12CC3CC(C1)CC(C3)(C2)NC(=O)OCc1ccccc1)OCc1ccccc1 |TLB:8:3:11:7.9.6,2:3:9:5.11.6,THB:4:5:12.3.8:9,4:3:9:5.11.6,8:7:11:12.3.4,2:3:11:7.9.6|
Structure:
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