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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM396035
Substrate
n/a
Meas. Tech.
SHP2 Allosteric Inhibition Assay
IC50
22.0±n/a nM
Citation
 Chen, Z; Fortanet, JG; LaMarche, MJ; Sendzik, M; Tamez, Jr., V; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10308660 Publication Date 6/4/2019 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM396035
Synonyms:
US10308660, Example 137
Type:
Small organic molecule
Emp. Form.:
C20H23Cl2F2N5O
Mol. Mass.:
458.332
SMILES:
Cn1c(nc(N)c(-c2cccc(Cl)c2Cl)c1=O)N1CCC2(CC(F)(F)C[C@H]2N)CC1 |r,wD:26.29,(.7,-1.7,;-.63,-.93,;-.63,.61,;-1.96,1.38,;-3.3,.61,;-4.63,1.38,;-3.3,-.93,;-4.63,-1.7,;-5.96,-.93,;-7.3,-1.7,;-7.3,-3.24,;-5.96,-4.01,;-5.96,-5.55,;-4.63,-3.24,;-3.3,-4.01,;-1.96,-1.7,;-1.96,-3.24,;.7,1.38,;2.04,.61,;3.37,1.38,;3.37,2.92,;4.78,2.3,;5.81,3.44,;6.9,2.35,;7.3,3.84,;5.04,4.78,;3.53,4.46,;2.44,5.55,;2.04,3.69,;.7,2.92,)|
Structure:
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