Reaction Details Report a problem with these data
Target
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Ligand
BDBM263614
Substrate
n/a
Meas. Tech.
Submitochondrial Particle Assay
pH
7.4±n/a
IC50
<100.0±n/a nM
Comments
extracted
Citation
 Cesati, RR; Radeke, HS; Pandey, SK; Purohit, A; Robinson, SP Compositions, methods, and systems for the synthesis and use of imaging agents US Patent  US9713651 Publication Date 7/25/2017 
Target
Name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Synonyms:
CI-51kD | Complex I-51kD | NADH dehydrogenase flavoprotein 1 | NADH-ubiquinone oxidoreductase 51 kDa subunit | NDUFV1 | NDUV1_BOVIN | UQOR1
Type:
PROTEIN
Mol. Mass.:
50659.85
Organism:
Bos taurus
Description:
EBI_100771
Residue:
464
Sequence:
MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRGDWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF
  
Inhibitor
Name:
BDBM263614
Synonyms:
2-fluoroethyl 4-(((1-(tert-butyl)-5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)oxy)methyl)benzoate | US9713651, 45
Type:
Small organic molecule
Emp. Form.:
C18H20ClFN2O4
Mol. Mass.:
382.814
SMILES:
CC(C)(C)n1ncc(OCc2ccc(cc2)C(=O)OCCF)c(Cl)c1=O
Structure:
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