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Target
TGF-beta receptor type-1 [T204D]
Ligand
BDBM396725
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
4.00±n/a nM
Citation
 Ding, P; Gelman, M; Kinsella, T; Singh, R; Bhamidipati, S; Velaparthi, U; Borzilleri, RM; Rahaman, H; Warrier, JS GDF-8 inhibitors US Patent  US9981944 Publication Date 5/29/2018 
Target
Name:
TGF-beta receptor type-1 [T204D]
Synonyms:
ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN
Type:
n/a
Mol. Mass.:
55981.22
Organism:
Homo sapiens (Human)
Description:
P36897[T204D]
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM396725
Synonyms:
N-(2-methoxyethyl)-6-(6'-methyl-[2,2'-bipyridin]- 3-yl)imidazo[1,2-a]pyridine-3-carboxamide | US9981944, Example 70
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
COCCNC(=O)c1cnc2ccc(cn12)-c1cccnc1-c1cccc(C)n1
Structure:
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