Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM317221
Substrate
n/a
Meas. Tech.
Enzymatic TDO Assay
IC50
10000±n/a nM
Citation
 Kumar, S; Waldo, J; Jaipuri, F; Mautino, M Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization US Patent  US9981973 Publication Date 5/29/2018 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase | T23O_HUMAN | TDO2 | TDO
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Human
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM317221
Synonyms:
US9617272, Compound 67 | US9981973, Compound 67
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: