Target

Ligand

Substrate

Meas. Tech.

Src IC50 Determination

pH

7.5±n/a

Temperature

296.15±n/a K

Citation

 Michalczyk, A; Klüter, S; Rode, HB; Simard, JR; Grütter, C; Rabiller, M; Rauh, D Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg Med Chem 16:3482-8 (2008) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Proto-oncogene tyrosine-protein kinase Src [251-533,S345C]

Synonyms:

Proto-oncogene tyrosine-protein kinase Src | SRC | SRC_CHICK | Src Mutant (S345C) | cSRC-SM

Type:

Tyr protein kinase

Mol. Mass.:

32702.38

Organism:

Gallus gallus (Chicken)

Description:

Mutation of S345 to cysteine was introduced by site-directed mutagenesis and confirmed by sequence analysis.

Residue:

286

Sequence:

GHMQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM4567

Synonyms:

4-anilinoquinazoline deriv. 2 | BMC163482 Compound 1 | CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide | US9422297, PD168393

Type:

Small organic molecule

Emp. Form.:

C17H13BrN4O

Mol. Mass.:

369.215

SMILES:

Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Tyr 02 Substrate Peptide

Synonyms:

n/a

Type:

FRET-peptide substrate

Mol. Mass.:

358.43

Organism:

n/a

Description:

n/a

Residue:

3

Sequence:

NA