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Target
Putative hydrolase
Ligand
BDBM398045
Substrate
n/a
Meas. Tech.
Biochemical Characterization of Cif Inhibitors
IC50
100000±2000 nM
Citation
 Madden, DR; Bahl, CD; Hammock, BD; Morisseau, C Compounds and methods for inhibiting Cif virulence factor US Patent  US10322118 Publication Date 6/18/2019 
Target
Name:
Putative hydrolase
Synonyms:
CFTR inhibitory factor, Cif | Putative hydrolase | cif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35786.52
Organism:
Pseudomonas aeruginosa (strain UCBPP-PA14)
Description:
A0A0H2ZD27
Residue:
319
Sequence:
MILDRLCRGLLAGIALTFSLGGFAAEEFPVPNGFESAYREVDGVKLHYVKGGQGPLVMLVHGFGQTWYEWHQLMPELAKRFTVIAPDLPGLGQSEPPKTGYSGEQVAVYLHKLARQFSPDRPFDLVAHDIGIWNTYPMVVKNQADIARLVYMEAPIPDARIYRFPAFTAQGESLVWHFSFFAADDRLAETLIAGKERFFLEHFIKSHASNTEVFSERLLDLYARSYAKPHSLNASFEYYRALNESVRQNAELAKTRLQMPTMTLAGGGHGGMGTFQLEQMKAYAEDVEGHVLPGCGHWLPEECAAPMNRLVIDFLSRGR
  
Inhibitor
Name:
BDBM398045
Synonyms:
US10322118, Entry 3
Type:
Small organic molecule
Emp. Form.:
C14H10I2O4
Mol. Mass.:
496.0357
SMILES:
OC(=O)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
Structure:
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